Scientist / Senior Scientist, Functional Genomics

San Diego, CA

  • We are seeking a creative, highly motivated, responsible and dynamic Scientist / Senior Scientist to join our R&D division to contribute to high-impact and fast-paced research and drug discovery.
  • This position is a full-time position in the company’s San Diego headquarters. 

Specific Responsibilities

  • Lead the identification and characterization of novel targets and mechanisms of tissue degeneration and disease (including, but not limited, to oncology, neuroscience, musculoskeletal, immunology, etc.).
  • Lead the application of leading-edge precision genome editing technologies for accelerated target evaluation.
  • Develop and execute genome-wide and/or targeted perturbation screens and combine with chemical perturbation phenotypes to develop actionable mechanistic hypotheses for novel target classes, chemical modes of action, and disease treatment strategies.
  • Develop appropriate in vitro biochemical, molecular and cell-based assays and in vivo models to investigate multiple cellular processes and phenotypes.
  • Interact routinely with Samumed’s Bioinformatics team to integrate knowledge and develop an understanding of complex biological systems
  • Develop mechanism of action hypotheses for genes and chemicals of unknown function to identify and validate ‘druggable’ targets”
  • Develop knowledge of and make recommendations about future applications of targets classes.
  • Engage in data analysis, presenting results, and working collaboratively with others to achieve objectives and timelines
  • Analyzing and documenting experimental data in electronic notebooks in a timely and accurate manner in accordance with the company rules
  • Presenting scientific data to colleagues and assisting in the preparation of internal and external presentations (oral, posters, and publications)
  • Manage 1-2 Research Associates as required

Requirements

  • Ph.D. in Biological Sciences or related field with at least 3+ years of post-doctoral training and/or 3+ years of pharmaceutical/ biotechnology industry experience.
  • Extensive knowledge and experience in human genetics, functional genomics and deep molecular phenotypic profiling for drug discovery.
  • Broad knowledge of Cellular Biology, Molecular Biology, Biochemistry, assay development.
  • Proficiency in mammalian cell culture, cellular, molecular assays and genetic as well as chemical perturbation screens.
  • Working knowledge of data analytics platforms and enabling computational biology tools preferred.
  • Experience working with bioinformaticians a plus.
  • Working knowledge of in vivo pharmacology preferred.
  • Proven track record of scientific contributions in chemical biology and functional genomics as evidenced by quality and quantity of publications and presentations.
  • Proven ability to collaborate in a team environment and work independently.
  • Excellent oral and written communication skills. Outstanding organizational and critical thinking skills.
  • Ability to provide novel creative solutions to challenging problems. Desire to learn and tackle new challenges and initiatives.
  • Level will be commensurate with experience

Please submit your resume or additional inquiries to apply@samumed.com. Please include the complete title of the position for which you are applying in the subject line of your email. Emails that do not include this information will be disregarded. NO PHONE CALLS PLEASE.