Scientist / Senior Scientist, Chemical Biology

San Diego, CA

  • We are seeking a creative, highly motivated, responsible and dynamic Scientist / Senior Scientist to join our R&D division to contribute to high-impact and fast-paced research and drug discovery.
  • This position is a full-time position in the company’s San Diego headquarters.

Specific Responsibilities

  • Lead the design and development of quantitative cellular, biochemical and/or biophysical assays to measure cellular target occupancy and establish mechanistic rationale for drug candidate identification.
  • Collaborate with chemists in the design and synthesis of compounds that can probe novel drug binding sites and elucidate the chemical features required for activity.
  • Apply genetic and/or quantitative proteomics methods (e.g. label-free, TMT, SILAC) to study pathways and identify targets.
  • Employ state-of-the-art assays for target and drug binding site identification and validation
  • Develop disease-relevant biochemical and cell-based assays to characterize compounds in close collaboration with our disease area experts (including, but not limited, to oncology, neuroscience, musculoskeletal, immunology, etc.).
  • Develop knowledge of and make recommendations about future applications of chemistry to tackle targets classes.
  • Engage in data analysis, presenting results, and working collaboratively with others to achieve objectives and timelines
  • Analyzing and documenting experimental data in electronic notebooks in a timely and accurate manner in accordance with the company rules
  • Presenting scientific data to colleagues and assisting in the preparation of internal and external presentations (oral, posters, and publications)
  • Manage 1-2 Research Associates as required

Requirements

  • Ph.D. in Chemical Biology, Biological Sciences or related field with at least 3+ years of post-doctoral training and/or 3+ years of pharmaceutical/ biotechnology industry experience.
  • Deep knowledge and experience in quantitative Chemical Biology techniques in drug discovery, target engagement, drug binding and evaluation is required.
  • Broad knowledge of Cellular Biology, Molecular Biology, Biochemistry, assay development.
  • Proficiency in mammalian cell culture, cellular, molecular and biochemical/biophysical assays and associated techniques.
  • Knowledge of MS-based data processing and analysis, including proteomics software. Experience working with bioinformaticians a plus.
  • Working knowledge of Chemistry and probe design a plus.
  • Proven track record of scientific contributions in chemical biology and functional genomics as evidenced by quality and quantity of publications and presentations.
  • Proven ability to collaborate in a team environment and work independently.
  • Excellent oral and written communication skills. Outstanding organizational and critical thinking skills.
  • Ability to provide novel creative solutions to challenging problems. Desire to learn and tackle new challenges and initiatives.
  • Level will be commensurate with experience

Please submit your resume or additional inquiries to apply@samumed.com. Please include the complete title of the position for which you are applying in the subject line of your email. Emails that do not include this information will be disregarded. NO PHONE CALLS PLEASE.