Scientist/Senior Scientist, Medicinal Chemistry

San Diego, CA

  • We are seeking multiple talented and highly motivated chemists with pharmaceutical industrial experience to join our drug discovery team.
  • The successful candidate will contribute to all phases of the drug discovery, including hit identification, hit to lead, lead optimization and candidate nomination.
  • As a member of a dynamic multi-disciplinary team, the candidate will work closely with other scientists internally or externally to support our drug discovery efforts and identify new chemical entities into clinical stage.
  • This is a full-time position in the company’s San Diego headquarters.

Specific Responsibilities

  • Design and optimize novel bioactive chemical entities in alignment with project goals based on the SAR analysis and by applying medicinal chemistry principles and tools.
  • Employ sound judgment in the evaluation and decision making on HTS hits and subsequent hit optimization follow-up.
  • Plan and execute the synthesis, purification and characterization of small molecules; develop scalable routes of preclinical drug-candidates.
  • Ability to overcome challenging synthetic problems with alternative and practical synthetic strategies.
  • Advance drug discovery programs by collaboratively interacting with other cross-functions to understand and optimize DMPK and in vitro and in vivo pharmacological properties.
  • Effectively manage and mentor junior medicinal chemistry colleagues and external CRO chemists.
  • Work closely with biologists to evaluate new programs and provide input on chemical tractability and analysis of literature leads.
  • Organize and prioritize workload to meet timelines and exhibit flexibility and adaptability within a rapidly changing and fast-paced environment.
  • Contribute to chemistry program strategy and serve as chemistry project lead for drug discovery programs.
  • Communicate effectively both in oral and written form and deliver internal and external presentations in a timely manner.
  • Perform routine maintenance on laboratory equipment and duty.
  • Contribute to the writing of patents, scientific presentations, and publications.

Requirements

  • Ph.D. in synthetic organic/medicinal chemistry with 3+ years of pharmaceutical industrial experience in small molecule drug discovery and development.
  • Demonstrated expertise in multi-step synthesis and strong knowledge of techniques related to purification and characterization of organic compounds (NMR, MS, HPLC, etc).
  • Demonstrated a high level of creativity and productivity with strong synthetic problem-solving skills; have clear command of organic synthesis and familiar with the current literature.
  • Good understanding of physicochemical, ADME, biochemical, pharmacology principles and effectively applying these in the design of novel small molecule drugs.
  • Experience in oncology/neurodegenerative research is a plus.
  • Proven track record in medicinal chemistry as evidenced by successful advancement of drug discovery projects and peer-reviewed publications.
  • Good understanding with structure-based drug design concept and experience using computational chemistry and data visualization software is a plus.
  • Able to work independently and apply experience and knowledge to solve difficult synthetic challenges and provide useful guidance to other chemists on the project team.
  • Experience in mentoring and managing both internal junior chemists and external chemistry resources is a plus.
  • Collaborate and communicate across a dynamic multi-disciplinary scientific team to successfully progress scientific goals.
  • Excellent written and oral communication skills including ability to present the data, issues and accomplishments of the team.

Please submit your resume or additional inquiries to apply@samumed.com. Please include the complete title of the position for which you are applying in the subject line of your email. Emails that do not include this information will be disregarded. NO PHONE CALLS PLEASE.