Overview: Alzheimer’s Disease
Alzheimer’s Disease (AD) is a chronic neurodegenerative disease affecting an estimated 5.8 million people in the United States (US)1 and over 46 million people worldwide.2
- It is the most common cause of dementia and currently available therapies treat symptoms, not the disease itself which is ultimately fatal.1
- With the world’s aging population, AD is quickly becoming “The Disease of the Century”3, a global epidemic and a socio-economic burden impacting families, social service, and healthcare delivery systems.1
Symptoms of AD generally occur in patients in their mid-60s, though symptoms may occur earlier in patients with familial forms of AD stemming from a genetic predisposition. The disease is initially characterized by progressive memory loss, and then slow progression to severe difficulty in accessing basic brain functions, prompting mental disorders.
Alzheimer’s Disease is a multifactorial disorder that involves several different etiopathological mechanisms ultimately leading to neurodegeneration illustrated at the cellular level by the presence of neurofibrillary tangles composed of the hyper-phosphorylated forms of the protein tau and insoluble β-amyloid plaques.
- Alzheimer’s Association. 2019 Alzheimer’s Disease Facts and Figures. Alzheimers Dement 2019;15(3):321-87
- Alzheimer’s Disease International. World Alzheimer’s Report 2015: The Global Impact of Dementia.http://www.alz.co.uk/research/WorldAlzheimerReport2015.pdf. Accessed 10/22/2016.
- Simpson SL. Alzheimer’s: The Disease of the Century. LinkedIn article. Website: https://www.linkedin.com/pulse/alzheimers-disease-century-shelby-l-simpson-basw. Accessed 10/22/16.