PK/PD Senior Scientist, Translational Sciences: Pharmacometrics

San Diego, CA

  • We are seeking highly motivated QSP/PKPD Modeling & Simulation Scientist who is driven to enhance drug development through quantitative modeling and simulation of PKPD and biological systems.
  • This role will be responsible of supporting PKPD-related and mathematical modeling activities in the PKDM space for drug discovery and development.
  • The Scientist in this role will work directly with other PKDM stakeholders to influence decision-making in the development of novel therapeutics including target/compound evaluation, design of preclinical studies, investigation of exposure-response relationships, design and execution of translational strategies, inform clinical study design.

Specific Responsibilities

  • Develop and apply mechanistic PKPD and systems pharmacology models in various therapeutic areas with a focus on oncology and neurodegenerative diseases. 
  • Implement quantitative analysis and strategies to inform decision making in drug development by using mathematical modeling and quantitative pharmacology principles with a focus on mechanistic and translational modeling
  • Apply PK and PK/PD modeling/simulation to guide the design and execution of in vivo preclinical animal experiments for efficacy and toxicology
  • Build effective collaboration with other scientists in Modeling and Simulation, Clinical Pharmacology, Clinical Science, Informatics, Biostatistics, Preclinical and Translational PK, DMPK, Safety Assessment, Biomarker, Diagnostics, Regulatory, and other functions.
  • Collaborate to develop robust translational and biomarker strategies for clinical candidates
  • Contribute to the analysis of in-vitro and pre-clinical PK/PD data for selection of first in humans (FIH) dose levels and contributes to IND submissions and documentation of appropriate reports.
  • Contribute to preparation of nonclinical documents in support of regulatory filings (INDs, NDAs, briefing books etc.)

Requirements

  • Ph.D. or M.S. in pharmaceutical sciences (PKPD concentration), mathematics, engineering, or other related disciplines
  • Experience 3+ years or master’s degree with 5+ years of experience in PK/PD modeling & simulation, quantitative pharmacology and applied population PK in the pharmaceutical industry
  • Expertise PK/PD analysis and modeling using Phoenix/WinNonlin, MATLAB /Simbiology, NONMEM, R etc., and/or experienced in the mathematical description and numerical solution of biological systems to address complex life sciences problems
  • PBPK modeling experience a plus 
  • Excellent oral and written communication skills
  • Must be a team-player, dependable and flexible in adapting to change in multidisciplinary, fast-paced R&D organization

Please submit your resume or additional inquiries to apply@samumed.com. Please include the complete title of the position for which you are applying in the subject line of your email. Emails that do not include this information will be disregarded. NO PHONE CALLS PLEASE.