Scientist, Immuno-Oncology and Tumor Microenvironment

San Diego, CA

  • We are seeking an innovative, highly motivated and creative Scientist to join our R&D division in the area of cancer immunology, with a focus on elucidating the molecular and cellular mechanisms underlying response and resistance to therapeutic intervention.  
  • This is a full-time position in the company’s San Diego headquarters.

Specific Responsibilities

  • Collaborative design and execution of integrative biological and computational evaluation of the immunomodulatory role of Samumed’s target class, including, but not limited to, the intersection of T/Bcells immunology, immune checkpoint blockade, immunomodulation of the tumor microenvironment, and the formation of neoantigens and neoepitopes.
  • Performs and supports ex vivo and heterotypic cell culture-based assays across relevant technology platforms (e.g., FACS, imaging, ELISA/MSD, Western Blot/WES, immunoprecipitation, RT-PCR, scRNA-Seq, CITE-Seq) to assess target modulation and downstream effects at cellular, protein and gene level.
  • Supports biomarker analysis of TCR repertoire sequencing from patient’s tumor biopsies. 
  • Manages multiple projects simultaneously and works cross-functionally with colleagues in the oncology, discovery, translational medicine, biomarker, bioinformatics, chemistry, and clinical groups.
  • Presents research findings to project teams and governance bodies and prepares technical reports.
  • Works with external academic, biotechnology, and contract research organizations to advance our understanding of oncology diseases.

Requirements

  • PhD in Cancer Immunology, Immunology, Tumor Biology, or a related discipline.
  • Hands-on experience in animal models of cancer or inflammation, including, but not limited to, humanized models, cell line-derived xenograft models, genetically engineered mouse models, adoptive immune cell transfer models, and/or in vivo tumor model-antigen platforms.
  • 2D and 3D cell culture, including establishment and maintenance of organoids.
  • Extensive experience in tumor/T cell/immune cell co-culture and/or antigen presentation assays in murine and/or human systems with knowledge of cell, biochemical and molecular analysis of immune cells including lymphoid and myeloid cells using flow cytometry, cytokine release assays, immunofluorescence imaging, cell proliferation assays, western blot, immunoprecipitation, qRT-PCR and other assays using small-molecule inhibitors and/or biologics.
  • Phenotypic and molecular analyses of primary tumor samples by imaging, multi-parameter flow cytometry, gene expression analysis, and next-generation sequencing
  • Proven publication record in immuno-oncology

Desirable

  • Experience with transcriptional profiling and bioinformatics (RNAseq, Nanostring)
  • Expertise working with large scale genomic data (e.g. TCRseq/BCRseq, T-ATACseq, CHIPseq) or with neoantigen prediction would be a distinct advantage.
  • Experience in evaluating drug combinations (methodology and software)
  • In vivo study design/execution and CRO management

Please submit your resume or additional inquiries to apply@samumed.com. Please include the complete title of the position for which you are applying in the subject line of your email. Emails that do not include this information will be disregarded. NO PHONE CALLS PLEASE.